The addition of specific ingredients into culture media to modulate host cells’ metabolism has also recently been explored. Among many strategies pursued, optimizing the complex nutritional requirements for cell growth and protein production has been frequently performed via culture media component titration and serum replacement. The ability to improve production yield is of important concern. Both rely on the capacity of different living factories, namely prokaryotic and eukaryotic cells, plants or animals for reliable and mass production. The global cell culture market is experiencing significant growth due to the rapid advancement in antibody-based and cell-based therapies. 3National University of Singapore (NUS) Graduate School for Integrative Sciences and Engineering, Singapore, Singapore.2Roquette Innovation Center, Helios, Singapore, Singapore.1Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore, Singapore.Jian Yao Ng 1, Mei Ling Chua 1, Chi Zhang 2, Shiqi Hong 2, Yogesh Kumar 2, Rajeev Gokhale 2 and Pui Lai Rachel Ee 1,3*
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